1. Hepatitis B vaccine (HepB). (Minimum age: birth) 

 At birth: 

• Administer monovalent HepB to all newborns before hospital discharge. 

• If mother is hepatitis B surface antigen (HBsAg)-positive, administer HepB  

and 0.5 mL of hepatitis B immune globulin (HBIG) within 12 hours of birth. 

• If mother’s HBsAg status is unknown, administer HepB within 12 hours of  

birth. Determine mother’s HBsAg status as soon as possible and, if  

HBsAg-positive, administer HBIG (no later than age 1 week). 

 After the birth dose: 

• The HepB series should be completed with either monovalent HepB or a  

combination vaccine containing HepB. The second dose should be  

administered at age 1 or 2 months. The final dose should be administered 

no earlier than age 24 weeks. 

• Infants born to HBsAg-positive mothers should be tested for HBsAg and  

antibody to HBsAg (anti-HBs) after completion of at least 3 doses of the  

HepB series, at age 9 through 18 months (generally at the next well-child visit). 

 4-month dose: 

• Administration of 4 doses of HepB to infants is permissible when combination 

vaccines containing HepB are administered after the birth dose. 

2. Rotavirus vaccine (RV). (Minimum age: 6 weeks) 

• Administer the first dose at age 6 through 14 weeks (maximum age:  

14 weeks 6 days). Vaccination should not be initiated for infants aged  

15 weeks or older (i.e., 15 weeks 0 days or older). 

• Administer the final dose in the series by age 8 months 0 days. 

• If Rotarix® is administered at ages 2 and 4 months, a dose at 6 months is 

not indicated. 

3.  Diphtheria and tetanus toxoids and acellular pertussis vaccine (DTaP). 

(Minimum age: 6 weeks) 

• The fourth dose may be administered as early as age 12 months, provided  

at least 6 months have elapsed since the third dose. 

• Administer the final dose in the series at age 4 through 6 years.  

4.  Haemophilus influenzae type b conjugate vaccine (Hib).  

(Minimum age: 6 weeks) 

• If PRP-OMP (PedvaxHIB® or Comvax® [HepB-Hib]) is administered at ages  

2 and 4 months, a dose at age 6 months is not indicated. 

• TriHiBit® (DTaP/Hib) should not be used for doses at ages 2, 4, or 6 months  

but can be used as the final dose in children aged 12 months or older. 

5.  Pneumococcal vaccine. (Minimum age: 6 weeks for pneumococcal conjugate 

vaccine [PCV]; 2 years for pneumococcal polysaccharide vaccine [PPSV]) 

• PCV is recommended for all children aged younger than 5 years.  

Administer 1 dose of PCV to all healthy children aged 24 through 59 

months who are not completely vaccinated for their age. 

• Administer PPSV to children aged 2 years or older with certain underlying  

medical conditions (see MMWR 2000;49[No. RR-9]), including a cochlear  

implant. 

6.  Influenza vaccine. (Minimum age: 6 months for trivalent inactivated  

influenza vaccine [TIV]; 2 years for live, attenuated influenza vaccine [LAIV]) 

• Administer annually to children aged 6 months through 18 years. 

• For healthy nonpregnant persons (i.e., those who do not have underlying  

medical conditions that predispose them to influenza complications) aged 

2 through 49 years, either LAIV or TIV may be used. 

• Children receiving TIV should receive 0.25 mL if aged 6 through 35 months  

or 0.5 mL if aged 3 years or older. 

• Administer 2 doses (separated by at least 4 weeks) to children aged younger 

than 9 years who are receiving influenza vaccine for the first time or who 

were vaccinated for the first time during the previous influenza season but 

only received 1 dose. 

7.   Measles, mumps, and rubella vaccine (MMR). (Minimum age: 12 months) 

• Administer the second dose at age 4 through 6 years. However, the second 

dose may be administered before age 4, provided at least 28 days have 

elapsed since the first dose. 

8. Varicella vaccine. (Minimum age: 12 months) 

• Administer the second dose at age 4 through 6 years. However, the second 

dose may be administered before age 4, provided at least 3 months have  

elapsed since the first dose. 

• For children aged 12 months through 12 years the minimum interval  

between doses is 3 months. However, if the second dose was administered 

at least 28 days after the first dose, it can be accepted as valid. 

9. Hepatitis A vaccine (HepA). (Minimum age: 12 months) 

• Administer to all children aged 1 year (i.e., aged 12 through 23 months).  

Administer 2 doses at least 6 months apart. 

• Children not fully vaccinated by age 2 years can be vaccinated at  

subsequent visits. 

• HepA also is recommended for children older than 1 year who live in areas  

where vaccination programs target older children or who are at increased 

risk of infection. See MMWR 2006;55(No. RR-7). 

10.  Meningococcal vaccine. (Minimum age: 2 years for meningococcal conjugate 

vaccine [MCV] and for meningococcal polysaccharide vaccine [MPSV])  

• Administer MCV to children aged 2 through 10 years with terminal complement 

component deficiency, anatomic or functional asplenia, and certain other 

high-risk groups. See MMWR 2005;54(No. RR-7). 

• Persons who received MPSV 3 or more years previously and who remain  

at increased risk for meningococcal disease should be revaccinated with MCV.